产品详情

  • 产品名称：Anti-FEM1A antibody (STJA0008830)

  • 产品型号：STJA0008830
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-FEM1A antibody (STJA0008830)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Protein fem-1 homolog A is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FEM1A
Gene ID: 55527
Uniprot ID: FEM1A_HUMAN
Specificity: This antibody detects endogenous levels of FEM1A at Human, Rat
Immunogen: Synthesized peptide derived from human FEM1A
Post Translational Modifications Phosphorylated.highly phosphorylated in myoblasts and myotubes. Phosphorylation at Ser-108 promotes PGE2-EP4-mediated inhibition of inflammation. Dephosphorylated by protein phosphatase 2A (PP2A).
Function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling.
Protein Name Protein Fem-1 Homolog A
Fem1a
Fem1-Alpha
Prostaglandin E Receptor 4-Associated Protein
Database Links Reactome: R-HSA-8951664
Cellular Localisation Mitochondrion
Cytoplasm
Alternative Antibody Names Anti-Protein Fem-1 Homolog A antibody
Anti-Fem1a antibody
Anti-Fem1-Alpha antibody
Anti-Prostaglandin E Receptor 4-Associated Protein antibody
Anti-FEM1A antibody
Anti-EPRAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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