产品详情

  • 产品名称：Anti-FLRT1 antibody (STJ192242)

  • 产品型号：STJ192242
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-FLRT1 antibody (STJ192242)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Leucine-rich repeat transmembrane protein FLRT1 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FLRT1
Gene ID: 23769
Uniprot ID: FLRT1_HUMAN
Specificity: FLRT1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications N-glycosylated. Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain.
Function Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.
Protein Name Leucine-Rich Repeat Transmembrane Protein Flrt1
Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1
Database Links Reactome: R-HSA-5654687
Cellular Localisation Cell Membrane
Single-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Cytoplasmic Vesicle Membrane
Cytoplasm
Perinuclear Region
Cell Junction
Focal Adhesion
Secreted
Cell Projection
Neuron Projection
In Addition To Its locations At The Cell Membrane
Colocalizes With Fgfr1 In Punctate Perinuclear Cytoplasmic Vesicles
Detected Along Neurites And At Contacts Between Neurite Termini And Other Cells
Proteolytic Cleavage Gives Rise To A Shedded Ectodomain
Alternative Antibody Names Anti-Leucine-Rich Repeat Transmembrane Protein Flrt1 antibody
Anti-Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1 antibody
Anti-FLRT1 antibody
Anti-UNQ752 antibody
Anti-PRO1483 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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