产品详情

  • 产品名称：Anti-FLG antibody (1-92) (STJ11101786)

  • 产品型号：STJ11101786
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-FLG antibody (1-92) (STJ11101786)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FLG (1-92) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FLG
Gene ID: 2312
Uniprot ID: FILA_HUMAN
Immunogen Region: 1-92
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human FLG (NP_002007.1).
Immunogen Sequence: MSTLLENIFAIINLFKQYSK KDKNTDTLSKKELKELLEKE FRQILKNPDDPDMVDVFMDH LDIDHNKKIDFTEFLLMVFK LAQAYYESTRKE
Tissue Specificity Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland. In the skin, mainly expressed in stratum granulosum of the epidermis.
Post Translational Modifications Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate. Undergoes deimination of some arginine residues (citrullination).
Function Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Protein Name Filaggrin
Database Links Reactome: R-HSA-6809371
Cellular Localisation Cytoplasmic Granule
In The Stratum Granulosum Of The Epidermis
Localized Within Keratohyalin Granules
In Granular Keratinocytes And In Lower Corneocytes
Colocalizes With Calpain-1/Capn1
Alternative Antibody Names Anti-Filaggrin antibody
Anti-FLG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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