产品详情

  • 产品名称：Anti-FERMT2 antibody (380-550) (STJ111384)

  • 产品型号：STJ111384
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-FERMT2 antibody (380-550) (STJ111384)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FERMT2 (380-550) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
IHC-P 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FERMT2
Gene ID: 10979
Uniprot ID: FERM2_HUMAN
Immunogen Region: 380-550
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 380-550 of human FERMT2 (NP_006823.1).
Immunogen Sequence: KVFKPKKLTLKGYKQYWCTF KDTSISCYKSKEESSGTPAH QMNLRGCEVTPDVNISGQKF NIKLLIPVAEGMNEIWLRCD NEKQYAHWMAACRLASKGKT MADSSYNLEVQNILSFLKMQ HLNPDPQLIPEQITTDITPE CLVSPRYLKKYKNKQITARI LEAHQNVAQMS
Tissue Specificity Ubiquitous. Found in numerous tumor tissues.
Function Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading.this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Protein Name Fermitin Family Homolog 2
Kindlin-2
Mitogen-Inducible Gene 2 Protein
Mig-2
Pleckstrin Homology Domain-Containing Family C Member 1
Ph Domain-Containing Family C Member 1
Database Links Reactome: R-HSA-446353
Reactome: R-HSA-9013149
Reactome: R-HSA-9013423
Cellular Localisation Cytoplasm
Cell Cortex
Cytoskeleton
Stress Fiber
Cell Junction
Focal Adhesion
Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Projection
Lamellipodsium Membrane
Nucleus
Myofibril
Sarcomere
I Band
Cell Surface
Colocalizes With Actin Stress Fibers At Cell-Ecm Focal Adhesion Sites
Colocalizes With Itgb3 At Lamellipodsia At The Leading Edge Of Spreading Cells
Binds To Membranes That Contain Phosphatidylinositides
Alternative Antibody Names Anti-Fermitin Family Homolog 2 antibody
Anti-Kindlin-2 antibody
Anti-Mitogen-Inducible Gene 2 Protein antibody
Anti-Mig-2 antibody
Anti-Pleckstrin Homology Domain-Containing Family C Member 1 antibody
Anti-Ph Domain-Containing Family C Member 1 antibody
Anti-FERMT2 antibody
Anti-KIND2 antibody
Anti-MIG2 antibody
Anti-PLEKHC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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