产品详情

  • 产品名称：Anti-FBXW7 antibody (N-Term) (STJA0005733)

  • 产品型号：STJA0005733-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-FBXW7 antibody (N-Term) (STJA0005733)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FBXW7 (N-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 0.02% NaN3
Purification: Antigen Affinity Purified
Dilution Range: WB 1:500-1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FBXW7
Gene ID: 55294
Uniprot ID: FBXW7_HUMAN
Immunogen Region: N-Term
Specificity: Reacts with the N terminus of the 69 kDa isoform of the hCdc4 protein
Immunogen: Synthetic peptide corresponding to amino acids from the N-terminal region of human Cdc4 protein
Post Translational Modifications Phosphorylation at Thr-205 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation. Phosphorylated by ATM at Ser-26 in response to DNA damage, promoting recruitment to DNA damage sites and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4. Ubiquitinated: autoubiquitinates following phosphorylation at Thr-205 and subsequent interaction with PIN1. Ubiquitination leads to its proteasomal degradation.
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. Involved in bone homeostasis and negative regulation of osteoclast differentiation. Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1.CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination. Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage. The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining.
Protein Name F-Box/Wd Repeat-Containing Protein 7
Archipelago Homolog
Hago
F-Box And Wd-40 Domain-Containing Protein 7
F-Box Protein Fbx30
Sel-10
Hcdc4
Database Links Reactome: R-HSA-2122947
Reactome: R-HSA-2644606
Reactome: R-HSA-2644607
Reactome: R-HSA-2894862
Reactome: R-HSA-390471
Reactome: R-HSA-8939902 Q969H0-1
Reactome: R-HSA-8951664
Reactome: R-HSA-9604323
Reactome: R-HSA-983168
Cellular Localisation Isoform 1: Nucleus
Nucleoplasm
Chromosome
Localizes To Site Of Double-Strand Breaks Following Phosphorylation By Atm
Isoform 2: Cytoplasm
Isoform 3: Nucleus
Nucleolus
Alternative Antibody Names Anti-F-Box/Wd Repeat-Containing Protein 7 antibody
Anti-Archipelago Homolog antibody
Anti-Hago antibody
Anti-F-Box And Wd-40 Domain-Containing Protein 7 antibody
Anti-F-Box Protein Fbx30 antibody
Anti-Sel-10 antibody
Anti-Hcdc4 antibody
Anti-FBXW7 antibody
Anti-FBW7 antibody
Anti-FBX30 antibody
Anti-SEL10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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