产品详情

  • 产品名称：Anti-EPHA4 antibody (540-620) (STJA0010092)

  • 产品型号：STJA0010092
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EPHA4 antibody (540-620) (STJA0010092)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ephrin type-A receptor 4 (540-620) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPHA4
Gene ID: 2043
Uniprot ID: EPHA4_HUMAN
Immunogen Region: 540-620
Specificity: This antibody detects endogenous levels of Human EphA4
Immunogen: Synthesized peptide derived from human EphA4 AA range: 540-620
Tissue Specificity Ubiquitous.
Function Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions. Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment.
Protein Name Ephrin Type-A Receptor 4
Eph-Like Kinase 8
Ek8
Hek8
Tyrosine-Protein Kinase Tyro1
Tyrosine-Protein Kinase Receptor Sek
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Reactome: R-HSA-9824272
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Axon
Dendrite
Postsynaptic Density Membrane
Early Endosome
Cell Junction
Adherens Junction
Clustered Upon Activation And Targeted To Early Endosome
Alternative Antibody Names Anti-Ephrin Type-A Receptor 4 antibody
Anti-Eph-Like Kinase 8 antibody
Anti-Ek8 antibody
Anti-Hek8 antibody
Anti-Tyrosine-Protein Kinase Tyro1 antibody
Anti-Tyrosine-Protein Kinase Receptor Sek antibody
Anti-EPHA4 antibody
Anti-HEK8 antibody
Anti-SEK antibody
Anti-TYRO1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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