产品详情

  • 产品名称：Anti-CD47 antibody (Internal) (STJ73432)

  • 产品型号：STJ73432-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD47 antibody (Internal) (STJ73432)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-CD47 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CD47
Gene ID: 961
Uniprot ID: CD47_HUMAN
Immunogen Region: Internal
Accession Number: NP_001768.1; NP_942088.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_001768.1; NP_942088.1).
Immunogen Sequence: SNQKTIQPPRK
Function Adhesive protein that mediates cell-to-cell interactions. Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering. Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging. In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells.
Protein Name Leukocyte Surface Antigen Cd47
Antigenic Surface Determinant Protein Oa3
Integrin-Associated Protein
Iap
Protein Mer6
Cd Antigen Cd47
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-391160
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Leukocyte Surface Antigen Cd47 antibody
Anti-Antigenic Surface Determinant Protein Oa3 antibody
Anti-Integrin-Associated Protein antibody
Anti-Iap antibody
Anti-Protein Mer6 antibody
Anti-Cd Antigen Cd47 antibody
Anti-CD47 antibody
Anti-MER6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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