产品详情

  • 产品名称：Anti-DRD4 antibody (1-100) (STJ23433)

  • 产品型号：STJ23433
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DRD4 antibody (1-100) (STJ23433)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DRD4 (1-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DRD4
Gene ID: 1815
Uniprot ID: DRD4_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DRD4 (P21917).
Immunogen Sequence: MGNRSTADADGLLAGRGPAA GASAGASAGLAGQGAAALVG GVLLIGAVLAGNSLVCVSVA TERALQTPTNSFIVSLAAAD LLLALLVLPLFVYSEVQGGA
Tissue Specificity Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary.
Post Translational Modifications Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein. Palmitoylated. Palmitoylation of the C-terminal Cys is important for normal expression at the cell membrane.
Function Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells.
Protein Name D(4 Dopamine Receptor
D(2c Dopamine Receptor
Dopamine D4 Receptor
Database Links Reactome: R-HSA-390651
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-D(4 Dopamine Receptor antibody
Anti-D(2c Dopamine Receptor antibody
Anti-Dopamine D4 Receptor antibody
Anti-DRD4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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