产品详情

  • 产品名称：Anti-DKC1 antibody (245-514) (STJ23384)

  • 产品型号：STJ23384
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DKC1 antibody (245-514) (STJ23384)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DKC1 (245-514) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DKC1
Gene ID: 1736
Uniprot ID: DKC1_HUMAN
Immunogen Region: 245-514
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 245-514 of human DKC1 (NP_001354.1).
Immunogen Sequence: ELRRVRSGVMSEKDHMVTMH DVLDAQWLYDNHKDESYLRR VVYPLEKLLTSHKRLVMKDS AVNAICYGAKIMLPGVLRYE DGIEVNQEIVVITTKGEAIC MAIALMTTAVISTCDHGIVA KIKRVIMERDTYPRKWGLGP KASQKKLMIKQGLLDKHGKP TDSTPATWKQEYVDYSESAK KEVVAEVVKAPQVVAEAAKT AKRKRESESESDETPPAAPQ LIKKEKKKSKKDKKAKAGL
Tissue Specificity Ubiquitously expressed.
Function Isoform 1: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression.
Protein Name H/Aca Ribonucleoprotein Complex Subunit Dkc1
Cbf5 Homolog
Dyskerin
Nopp140-Associated Protein Of 57 Kda
Nucleolar Protein Nap57
Nucleolar Protein Family A Member 4
Snornp Protein Dkc1
Database Links Reactome: R-HSA-171319
Reactome: R-HSA-6790901
Cellular Localisation Isoform 1: Nucleus
Nucleolus
Nucleus
Cajal Body
Also Localized To Cajal Bodies (Coiled Bodies)
Isoform 3: Cytoplasm
Alternative Antibody Names Anti-H/Aca Ribonucleoprotein Complex Subunit Dkc1 antibody
Anti-Cbf5 Homolog antibody
Anti-Dyskerin antibody
Anti-Nopp140-Associated Protein Of 57 Kda antibody
Anti-Nucleolar Protein Nap57 antibody
Anti-Nucleolar Protein Family A Member 4 antibody
Anti-Snornp Protein Dkc1 antibody
Anti-DKC1 antibody
Anti-NOLA4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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