产品详情

  • 产品名称：Anti-DHCR24 antibody (227-516) (STJ27355)

  • 产品型号：STJ27355
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DHCR24 antibody (227-516) (STJ27355)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DHCR24 (227-516) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DHCR24
Gene ID: 1718
Uniprot ID: DHC24_HUMAN
Immunogen Region: 227-516
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 (NP_055577.1).
Immunogen Sequence: AEIRIIPAKKYVKLRFEPVR GLEAICAKFTHESQRQENHF VEGLLYSLDEAVIMTGVMTD EAEPSKLNSIGNYYKPWFFK HVENYLKTNREGLEYIPLRH YYHRHTRSIFWELQDIIPFG NNPIFRYLFGWMVPPKISLL KLTQGETLRKLYEQHHVVQD MLVPMKCLQQALHTFQNDIH VYPIWLCPFILPSQPGLVHP KGNEAELYIDIGAYGEPRVK HFEARSCMRQLEKFVRSVH
Tissue Specificity Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
Function Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosesynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
Protein Name Delta(24-Sterol Reductase
24-Dehydrocholesterol Reductase
3-Beta-Hydroxysterol Delta-24-Reductase
Diminuto/Dwarf1 Homolog
Seladin-1
Database Links Reactome: R-HSA-191273
Reactome: R-HSA-6807047
Reactome: R-HSA-6807062
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Golgi Apparatus Membrane
Alternative Antibody Names Anti-Delta(24-Sterol Reductase antibody
Anti-24-Dehydrocholesterol Reductase antibody
Anti-3-Beta-Hydroxysterol Delta-24-Reductase antibody
Anti-Diminuto/Dwarf1 Homolog antibody
Anti-Seladin-1 antibody
Anti-DHCR24 antibody
Anti-KIAA0018 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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