产品详情

  • 产品名称：Anti-DELE1 antibody (STJA0008739)

  • 产品型号：STJA0008739
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DELE1 antibody (STJA0008739)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DAP3-binding cell death enhancer 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DELE1
Gene ID: 9812
Uniprot ID: DELE1_HUMAN
Specificity: This antibody detects endogenous levels of DELE1 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human DELE1
Post Translational Modifications DAP3-binding cell death enhancer 1: Unstable protein in absence of stress: imported in the mitochondrial matrix following processing by the mitochondrial-processing peptidase (MPP), where it is degraded by LONP1. Stabilized in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting localization at the mitochondrial surface and stabilization. Cleaved by OMA1 in response to mitochondrial stress, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1) that accumulates in the cytosol and activates the protein kinase activity of EIF2AK1/HRI. Protein cleavage by OMA1 can take place at different positions, and apparently does not require a specific sequence motif.
Function Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency and mitochondrial stress. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation. DAP3-binding cell death enhancer 1: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. DAP3-binding cell death enhancer 1 short form: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR.
Protein Name Dap3-Binding Cell Death Enhancer 1
Dap3-Binding Cell Death Enhancer 1 - Long Form
Dele1(L
Death Ligand Signal Enhancer Cleaved Into - Dap3-Binding Cell Death Enhancer 1 Short Form
Dele1(S
S-Dele1
Cellular Localisation Dap3-Binding Cell Death Enhancer 1: Mitochondrion
Mitochondrion Outer Membrane
Mitochondrion Inner Membrane
Imported In The Mitochondrial Matrix In Absence Of Stress
Leading To Its Degradation By Lonp1
Localizes At The Mitochondrial Surface In Response To Iron Deficiency: Iron Deficiency Impairs Mitochondrial Import
Promoting Localization At The Mitochondrial Surface And Stabilization
Associates With The Mitochondrion Inner Membrane In Response To Mitochondrial Stress
Leading To Its Proteolytic Processing By Oma1
And Generation Of The Ap3-Binding Cell Death Enhancer 1 Short Form (Dele1(S) Or S-Dele1)
Dap3-Binding Cell Death Enhancer 1 Short Form: Cytoplasm
Cytosol
This Short Form Is Generated By Proteolytic Processing By Oma1 In Response To Mitochondrial Stress
Leading To Translocations To The Cytosol
Alternative Antibody Names Anti-Dap3-Binding Cell Death Enhancer 1 antibody
Anti-Dap3-Binding Cell Death Enhancer 1 - Long Form antibody
Anti-Dele1(L antibody
Anti-Death Ligand Signal Enhancer Cleaved Into - Dap3-Binding Cell Death Enhancer 1 Short Form antibody
Anti-Dele1(S antibody
Anti-S-Dele1 antibody
Anti-DELE1 antibody
Anti-DELE antibody
Anti-KIAA0141 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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