产品详情

  • 产品名称：Anti-DCC antibody (1330-1380) {FITC} (STJ500740)

  • 产品型号：STJ500740-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DCC antibody (1330-1380) {FITC} (STJ500740)
详情介绍：
Host: Rabbit
Applications: ELISA/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DCC (1330-1380) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.50 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: DCC
Gene ID: 1630
Uniprot ID: DCC_HUMAN
Immunogen Region: 1330-1380
Immunogen: Synthetic peptide taken within amino acid region 1330-1380 on rat DCC protein.
Tissue Specificity Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
Post Translational Modifications Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Protein Name Netrin Receptor Dcc
Colorectal Cancer Suppressor
Immunoglobulin Superfamily Dcc Subclass Member 1
Tumor Suppressor Protein Dcc
Database Links Reactome: R-HSA-373752
Reactome: R-HSA-376172
Reactome: R-HSA-418885
Reactome: R-HSA-418886
Reactome: R-HSA-418889
Reactome: R-HSA-418890
Reactome: R-HSA-428542
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Netrin Receptor Dcc antibody
Anti-Colorectal Cancer Suppressor antibody
Anti-Immunoglobulin Superfamily Dcc Subclass Member 1 antibody
Anti-Tumor Suppressor Protein Dcc antibody
Anti-DCC antibody
Anti-IGDCC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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