产品详情

  • 产品名称：Anti-FBL antibody (STJA0006907)

  • 产品型号：STJA0006907
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-FBL antibody (STJA0006907)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-rRNA 2 O-methyltransferase fibrillarin is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FBL
Gene ID: 2091
Uniprot ID: FBRL_HUMAN
Specificity: This antibody detects endogenous levels of FBL at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human FBL
Function S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Protein Name Rrna 2'-O-Methyltransferase Fibrillarin
34 Kda Nucleolar Scleroderma Antigen
Histone-Glutamine Methyltransferase
U6 Snrna 2'-O-Methyltransferase Fibrillarin
Database Links Reactome: R-HSA-6790901
Reactome: R-HSA-6791226
Cellular Localisation Nucleus
Nucleolus
Nucleoplasm
Fibrillar Region Of The Nucleolus
Alternative Antibody Names Anti-Rrna 2'-O-Methyltransferase Fibrillarin antibody
Anti-34 Kda Nucleolar Scleroderma Antigen antibody
Anti-Histone-Glutamine Methyltransferase antibody
Anti-U6 Snrna 2'-O-Methyltransferase Fibrillarin antibody
Anti-FBL antibody
Anti-FIB1 antibody
Anti-FLRN antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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