产品详情

  • 产品名称：Anti-FANCM antibody (440-490 aa) (STJ190816)

  • 产品型号：STJ190816
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-FANCM antibody (440-490 aa) (STJ190816)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Fanconi anemia group M protein (440-490 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FANCM
Gene ID: 57697
Uniprot ID: FANCM_HUMAN
Immunogen Region: 440-490 aa
Specificity: FANCM Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein at the amino acid 440-490
Post Translational Modifications Phosphorylated.hyperphosphorylated in response to genotoxic stress.
Function DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.
Protein Name Fanconi Anemia Group M Protein
Protein Facm
Atp-Dependent Rna Helicase Fancm
Fanconi Anemia-Associated Polypeptide Of 250 Kda
Faap250
Protein Hef Ortholog
Database Links Reactome: R-HSA-6783310
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Fanconi Anemia Group M Protein antibody
Anti-Protein Facm antibody
Anti-Atp-Dependent Rna Helicase Fancm antibody
Anti-Fanconi Anemia-Associated Polypeptide Of 250 Kda antibody
Anti-Faap250 antibody
Anti-Protein Hef Ortholog antibody
Anti-FANCM antibody
Anti-KIAA1596 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 
网站地图