产品详情

  • 产品名称：Anti-FA2H antibody (95-170) (STJ115812)

  • 产品型号：STJ115812
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-FA2H antibody (95-170) (STJ115812)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FA2H (95-170) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FA2H
Gene ID: 79152
Uniprot ID: FA2H_HUMAN
Immunogen Region: 95-170
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 95-170 of human FA2H (NP_077282.3).
Immunogen Sequence: NEPVALEETQKTDPAMEPRF KVVDWDKDLVDWRKPLLWQV GHLGEKYDEWVHQPVTRPIR LFHSDLIEGLSKTVWY
Tissue Specificity Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes. Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney.
Function Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
Protein Name Fatty Acid 2-Hydroxylase
Fatty Acid Alpha-Hydroxylase
Fatty Acid Hydroxylase Domain-Containing Protein 1
Database Links Reactome: R-HSA-1660661
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Microsome Membrane
Alternative Antibody Names Anti-Fatty Acid 2-Hydroxylase antibody
Anti-Fatty Acid Alpha-Hydroxylase antibody
Anti-Fatty Acid Hydroxylase Domain-Containing Protein 1 antibody
Anti-FA2H antibody
Anti-FAAH antibody
Anti-FAXDC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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