产品详情

  • 产品名称：Anti-EXOSC3 antibody (1-275) (STJ113228)

  • 产品型号：STJ113228
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EXOSC3 antibody (1-275) (STJ113228)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EXOSC3 (1-275) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EXOSC3
Gene ID: 51010
Uniprot ID: EXOS3_HUMAN
Immunogen Region: 1-275
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human EXOSC3 (NP_057126.2).
Immunogen Sequence: MAEPASVAAESLAGSRARAA RTVLGQVVLPGEELLLPEQE DAEGPGGAVERPLSLNARAC SRVRVVCGPGLRRCGDRLLV TKCGRLRHKEPGSGSGGGVY WVDSQQKRYVPVKGDHVIGI VTAKSGDIFKVDVGGSEPAS LSYLSFEGATKRNRPNVQVG DLIYGQFVVANKDMEPEMVC IDSCGRANGMGVIGQDGLLF KVTLGLIRKLLAPDCEIIQE VGKLYPLEIVFGMNGRIWV
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.
Protein Name Exosome Complex Component Rrp40
Exosome Component 3
Ribosomal Rna-Processing Protein 40
P10
Database Links Reactome: R-HSA-380994
Reactome: R-HSA-429958
Reactome: R-HSA-450385
Reactome: R-HSA-450513
Reactome: R-HSA-450604
Reactome: R-HSA-6791226
Cellular Localisation Cytoplasm
Nucleus
Nucleolus
Alternative Antibody Names Anti-Exosome Complex Component Rrp40 antibody
Anti-Exosome Component 3 antibody
Anti-Ribosomal Rna-Processing Protein 40 antibody
Anti-P10 antibody
Anti-EXOSC3 antibody
Anti-RRP40 antibody
Anti-CGI-102 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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