产品详情

  • 产品名称：Anti-ETF1 antibody (STJA0009681)

  • 产品型号：STJA0009681
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ETF1 antibody (STJA0009681)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Eukaryotic peptide chain release factor subunit 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ETF1
Gene ID: 2107
Uniprot ID: ERF1_HUMAN
Specificity: This antibody detects endogenous levels of ETF1 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human ETF1
Function Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.
Protein Name Eukaryotic Peptide Chain Release Factor Subunit 1
Eukaryotic Release Factor 1
Erf1
Protein Cl1
Tb3-1
Database Links Reactome: R-HSA-72764
Reactome: R-HSA-9010553
Reactome: R-HSA-975956
Reactome: R-HSA-975957
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Eukaryotic Peptide Chain Release Factor Subunit 1 antibody
Anti-Eukaryotic Release Factor 1 antibody
Anti-Erf1 antibody
Anti-Protein Cl1 antibody
Anti-Tb3-1 antibody
Anti-ETF1 antibody
Anti-ERF1 antibody
Anti-RF1 antibody
Anti-SUP45L1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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