产品详情

  • 产品名称：Anti-EIF3L antibody (1-230) (STJ112013)

  • 产品型号：STJ112013
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EIF3L antibody (1-230) (STJ112013)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EIF3L (1-230) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:4000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF3L
Gene ID: 51386
Uniprot ID: EIF3L_HUMAN
Immunogen Region: 1-230
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human EIF3L (NP_057175.1).
Immunogen Sequence: MSYPADDYESEAAYDPYAYP SDYDMHTGDPKQDLAYERQY EQQTYQVIPEVIKNFIQYFH KTVSDLIDQKVYELQASRVS SDVIDQKVYEIQDIYENSWT KLTERFFKNTPWPEAEAIAP QVGNDAVFLILYKELYYRHI YAKVSGGPSLEQRFESYYNY CNLFNYILNADGPAPLELPN QWLWDIIDEFIYQFQSFSQY RCKTAKKSEEEIDFLRSNPK IWNVHSVLNV
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
Protein Name Eukaryotic Translation Initiation Factor 3 Subunit L
Eif3l
Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein
Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-72649
Reactome: R-HSA-72689
Reactome: R-HSA-72695
Reactome: R-HSA-72702
Reactome: R-HSA-72706
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 3 Subunit L antibody
Anti-Eif3l antibody
Anti-Eukaryotic Translation Initiation Factor 3 Subunit 6-Interacting Protein antibody
Anti-Eukaryotic Translation Initiation Factor 3 Subunit E-Interacting Protein antibody
Anti-EIF3L antibody
Anti-EIF3EIP antibody
Anti-EIF3S6IP antibody
Anti-HSPC021 antibody
Anti-HSPC025 antibody
Anti-MSTP005 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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