产品详情

  • 产品名称：Anti-EIF2AK3 antibody (580-720) [S4246RM] (STJ11104246)

  • 产品型号：STJ11104246
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EIF2AK3 antibody (580-720) [S4246RM] (STJ11104246)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3 (580-720) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S4246RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF2AK3
Gene ID: 9451
Uniprot ID: E2AK3_HUMAN
Immunogen Region: 580-720
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 580-720 of human PERK (NP_004827.4).
Immunogen Sequence: IKNSGYISRYLTDFEPIQCL GRGGFGVVFEAKNKVDDCNY AIKRIRLPNRELAREKVMRE VKALAKLEHPGIVRYFNAWL EAPPEKWQEKMDEIWLKDES TDWPLSSPSPMDAPSVKIRR MDPFATKEHIEIIAPSPQRS R
Tissue Specificity Ubiquitous. A high level expression is seen in secretory tissues.
Post Translational Modifications Oligomerization of the N-terminal ER luminal domain by ER stress promotes PERK trans-autophosphorylation of the C-terminal cytoplasmic kinase domain at multiple residues including Thr-982 on the kinase activation loop. Autophosphorylated. Phosphorylated at Tyr-619 following endoplasmic reticulum stress, leading to activate its tyrosine-protein kinase activity. Dephosphorylated by PTPN1/TP1B, leading to inactivate its enzyme activity. N-glycosylated. ADP-ribosylated by PARP16 upon ER stress, which increases kinase activity.
Function Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Protein Name Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3
Prkr-Like Endoplasmic Reticulum Kinase
Pancreatic Eif2-Alpha Kinase
Hspek
Database Links Reactome: R-HSA-381042
Reactome: R-HSA-9700645
Reactome: R-HSA-9725370
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3 antibody
Anti-Prkr-Like Endoplasmic Reticulum Kinase antibody
Anti-Pancreatic Eif2-Alpha Kinase antibody
Anti-Hspek antibody
Anti-EIF2AK3 antibody
Anti-PEK antibody
Anti-PERK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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