产品详情

  • 产品名称：Anti-EGLN1 antibody (STJA0007170)

  • 产品型号：STJA0007170
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EGLN1 antibody (STJA0007170)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Egl nine homolog 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EGLN1
Gene ID: 54583
Uniprot ID: EGLN1_HUMAN
Specificity: This antibody detects endogenous levels of PHD2/EGLN1 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human PHD2/EGLN1
Post Translational Modifications S-nitrosylation inhibits the enzyme activity up to 60% under aerobic conditions. Chelation of Fe(2+) has no effect on the S-nitrosylation. It is uncertain whether nitrosylation occurs on Cys-323 or Cys-326.
Function Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocations to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
Protein Name Egl Nine Homolog 1
Hypoxia-Inducible Factor Prolyl Hydroxylase 2
Hif-Ph2
Hif-Prolyl Hydroxylase 2
Hph-2
Prolyl Hydroxylase Domain-Containing Protein 2
Phd2
Sm-20
Database Links Reactome: R-HSA-1234176
Cellular Localisation Cytoplasm
Nucleus
Mainly Cytoplasmic
Shuttles Between The Nucleus And Cytoplasm
Nuclear Export Requires Functional Xpo1
Alternative Antibody Names Anti-Egl Nine Homolog 1 antibody
Anti-Hypoxia-Inducible Factor Prolyl Hydroxylase 2 antibody
Anti-Hif-Ph2 antibody
Anti-Hif-Prolyl Hydroxylase 2 antibody
Anti-Hph-2 antibody
Anti-Prolyl Hydroxylase Domain-Containing Protein 2 antibody
Anti-Phd2 antibody
Anti-Sm-20 antibody
Anti-EGLN1 antibody
Anti-C1orf12 antibody
Anti-PNAS-118 antibody
Anti-PNAS-137 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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