产品详情

  • 产品名称：Mouse LCAT (Lecithin Cholesterol Acyltransferase) Sandwich ELISA Kit Ready-To-Use (STJE0016663)

  • 产品型号：STJE0016663
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse LCAT (Lecithin Cholesterol Acyltransferase) Sandwich ELISA Kit Ready-To-Use (STJE0016663)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 6.9pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This LCAT Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Lcat
Gene ID: 16816
Uniprot ID: LCAT_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Detected in blood plasma. Produced and secreted by astrocytes (at protein level). Abundantly expressed in liver, brain and testis with highest levels in liver. In the brain, found in cerebellum, cerebral cortex, hippocampus and brain stem. Located to neurons and neuroglia.
Post Translational Modifications
Function Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF. Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters.
Protein Name Phosphatidylcholine-Sterol Acyltransferase
1-Alkyl-2-Acetylglycerophosphocholine Esterase
Lecithin-Cholesterol Acyltransferase
Phospholipid-Cholesterol Acyltransferase
Platelet-Activating Factor Acetylhydrolase
Paf Acetylhydrolase
Database Links Reactome: R-MMU-8964058
Cellular Localisation Secreted
Secreted Into Blood Plasma
Produced In Astrocytes And Secreted Into Cerebral Spinal Fluid (Csf)
Alternative ELISA Names Phosphatidylcholine-Sterol Acyltransferase ELISA kit
1-Alkyl-2-Acetylglycerophosphocholine Esterase ELISA kit
Lecithin-Cholesterol Acyltransferase ELISA kit
Phospholipid-Cholesterol Acyltransferase ELISA kit
Platelet-Activating Factor Acetylhydrolase ELISA kit
Paf Acetylhydrolase ELISA kit
Lcat ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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