产品详情

  • 产品名称：Mouse ITGa4 (Integrin Alpha 4) Sandwich ELISA Kit (STJE0010082)

  • 产品型号：STJE0010082
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse ITGa4 (Integrin Alpha 4) Sandwich ELISA Kit (STJE0010082)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.071ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ITGa4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Itga4
Gene ID: 16401
Uniprot ID: ITA4_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Peyer patch homing cells.
Post Translational Modifications Phosphorylation on Ser-1028 inhibits PXN binding.
Function Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.
Protein Name Integrin Alpha-4
Cd49 Antigen-Like Family Member D
Integrin Alpha-Iv
Lymphocyte Peyer Patch Adhesion Molecules Subunit Alpha
Lpam Subunit Alpha
Vla-4 Subunit Alpha
Cd Antigen Cd49d
Database Links Reactome: R-MMU-198933
Reactome: -MMU-202733
Reactome: -MMU-216083
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative ELISA Names Integrin Alpha-4 ELISA kit
Cd49 Antigen-Like Family Member D ELISA kit
Integrin Alpha-Iv ELISA kit
Lymphocyte Peyer Patch Adhesion Molecules Subunit Alpha ELISA kit
Lpam Subunit Alpha ELISA kit
Vla-4 Subunit Alpha ELISA kit
Cd Antigen Cd49d ELISA kit
Itga4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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