产品详情

  • 产品名称：Mouse IRS1 (Insulin Receptor Substrate 1) Sandwich ELISA Kit Ready-To-Use (STJE0016449)

  • 产品型号：STJE0016449
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse IRS1 (Insulin Receptor Substrate 1) Sandwich ELISA Kit Ready-To-Use (STJE0016449)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.124ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This IRS1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Irs1
Gene ID: 16367
Uniprot ID: IRS1_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in osteoblasts, but not in osteoclasts.
Post Translational Modifications Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-307 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor. Phosphorylation of Tyr-891 is required for GRB2-binding. Phosphorylated by ALK. Phosphorylated at Ser-265, Ser-302, Ser-632 and Ser-1097 by RPS6KB1.phosphorylation induces accelerated degradation of IRS1. Phosphorylated on tyrosine residues in response to insulin. In skeletal muscles, dephosphorylated on Tyr-608 by TNS2 under anabolic conditions.dephosphorylation results in the proteasomal degradation of IRS1. Ubiquitinated by the Cul7-RING(FBXW8) complex in a mTOR-dependent manner, leading to its degradation: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2).
Function May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Protein Name Insulin Receptor Substrate 1
Irs-1
Database Links Reactome: R-MMU-109704
Reactome: -MMU-112399
Reactome: -MMU-112412
Reactome: -MMU-1257604
Reactome: -MMU-1266695
Reactome: -MMU-198203
Reactome: -MMU-201556
Reactome: -MMU-2428928
Reactome: -MMU-5673001
Reactome: -MMU-6811558
Reactome: -MMU-74713
Reactome: -MMU-74749
Cellular Localisation
Alternative ELISA Names Insulin Receptor Substrate 1 ELISA kit
Irs-1 ELISA kit
Irs1 ELISA kit
Irs-1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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