产品详情

  • 产品名称：Anti-DTX1 antibody (STJA0008154)

  • 产品型号：STJA0008154
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DTX1 antibody (STJA0008154)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase DTX1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DTX1
Gene ID: 1840
Uniprot ID: DTX1_HUMAN
Specificity: This antibody detects endogenous levels of DTX1 at Human, Mouse
Immunogen: Synthesized peptide derived from human DTX1
Post Translational Modifications Ubiquitinated.undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.
Function Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
Protein Name E3 Ubiquitin-Protein Ligase Dtx1
Protein Deltex-1
Deltex1
Hdtx1
Ring-Type E3 Ubiquitin Transferase Dtx1
Database Links Reactome: R-HSA-2122948
Cellular Localisation Cytoplasm
Nucleus
Predominantly Cytoplasmic
Associates With Endocytic Vesicles
Partially Nuclear
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Dtx1 antibody
Anti-Protein Deltex-1 antibody
Anti-Deltex1 antibody
Anti-Hdtx1 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Dtx1 antibody
Anti-DTX1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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