产品详情

  • 产品名称：Anti-DTL antibody (STJ193050)

  • 产品型号：STJ193050
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DTL antibody (STJ193050)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Denticleless protein homolog denticleless protein homolog is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DTL
Gene ID: 51514
Uniprot ID: DTL_HUMAN
Specificity: DTL Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C). Autoubiquitinated through 'Lys-48'-polyubiquitin chains in a PCNA-independent reaction, allowing proteasomal turnover. Polyubiquitinated by SCF(FBXO11) when not phosphorylated, leading to its degradation. A tight regulation of the polyubiquitination by SCF(FBXO11) is involved in the control of different processes such as TGF-beta signaling, cell cycle progression and exit. Phosphorylated at Thr-464 by CDK1/Cyclin-B and CDK2/Cyclin-A but not by CDK2/Cyclin-E, MAPK1 or PLK1. Phosphorylation at Thr-464 inhibits the interaction with FBXO11 and decreases upon cell cycle exit induced by TGF-beta or serum starvation.
Function Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1.
Protein Name Denticleless Protein Homolog
Ddb1- And Cul4-Associated Factor 2
Lethal(2 Denticleless Protein Homolog
Retinoic Acid-Regulated Nuclear Matrix-Associated Protein
Database Links Reactome: R-HSA-110314
Reactome: R-HSA-8951664
Cellular Localisation Nucleus
Nucleus Membrane
Peripheral Membrane Protein
Nucleoplasmic Side
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Chromosome
Nuclear Matrix-Associated Protein
Translocates From The Interphase Nucleus To The Metaphase Cytoplasm During Mitosis
Alternative Antibody Names Anti-Denticleless Protein Homolog antibody
Anti-Ddb1- And Cul4-Associated Factor 2 antibody
Anti-Lethal(2 Denticleless Protein Homolog antibody
Anti-Retinoic Acid-Regulated Nuclear Matrix-Associated Protein antibody
Anti-DTL antibody
Anti-CDT2 antibody
Anti-CDW1 antibody
Anti-DCAF2 antibody
Anti-L2DTL antibody
Anti-RAMP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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