产品详情
简单介绍：
Anti-DST antibody (STJA0008546)
详情介绍：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Dystonin is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DST |
| Gene ID: | 667 |
| Uniprot ID: | DYST_HUMAN |
| Specificity: | This antibody detects endogenous levels of DST at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human DST |
| Function | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1. Isoform 3: Plays a structural role in the assembly of hemidesmosomes of epithelial cells.anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility.mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: Required for bundling actin filaments around the nucleus. Isoform 7: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Protein Name | Dystonin 230 Kda Bullous Pemphigoid Antigen 230/240 Kda Bullous Pemphigoid Antigen Bullous Pemphigoid Antigen 1 Bpa Bullous Pemphigoid Antigen Dystonia Musculorum Protein Hemidesmosomal Plaque Protein |
| Database Links | Reactome: R-HSA-2022090 Q03001-3 Reactome: R-HSA-446107 Reactome: R-HSA-9013420 Reactome: R-HSA-9013424 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273 |
| Cellular Localisation | Cytoplasm Cytoskeleton Stress Fiber Cell Projection Axon Associates With Intermediate Filaments Actin And Microtubule Cytoskeletons Localizes To Actin Stress Fibers And To Actin-Rich Ruffling At The Cortex Of Cells Associated At The Growing Distal Tip Of Microtubules Isoform 1: Cytoplasm Myofibril Sarcomere Z Line H Zone Localizes To Microtubules And Actin Microfilaments Throughout The Cytoplasm And At Focal Contact Attachments At The Plasma Membrane Isoform 2: Cytoplasm Colocalizes Both Cortical And Cytoplasmic Actin Filaments Isoform 3: Cytoplasm Cell Junction Hemidesmosome Localizes To Actin And Intermediate Filaments Cytoskeletons Colocalizes With The Epidermal Krt5-Krt14 Intermediate Filaments Network Of Keratins Colocalizes With Itgb4 At The Leading Edge Of Migrating Keratinocytes Isoform 6: Nucleus Nucleus Envelope Membrane Single-Pass Membrane Protein Endoplasmic Reticulum Membrane Localizes To Central Actin Stress Fibers Around The Nucleus And Is Excluded Form Focal Contact Sites In Myoblast Cells Translocates To The Nucleus Associates With Actin Cytoskeleton In Sensory Neurons Isoform 7: Cytoplasm Associates With Axonal Microtubules And Intermediate Filaments But Not With Actin Cytoskeleton In Sensory Neurons Isoform 8: Cytoplasm Cell Cortex Cell Membrane Lipid-Anchor |
| Alternative Antibody Names | Anti-Dystonin antibody Anti-230 Kda Bullous Pemphigoid Antigen antibody Anti-230/240 Kda Bullous Pemphigoid Antigen antibody Anti-Bullous Pemphigoid Antigen 1 antibody Anti-Bpa antibody Anti-Bullous Pemphigoid Antigen antibody Anti-Dystonia Musculorum Protein antibody Anti-Hemidesmosomal Plaque Protein antibody Anti-DST antibody Anti-BP230 antibody Anti-BP240 antibody Anti-BPAG1 antibody Anti-DMH antibody Anti-DT antibody Anti-KIAA0728 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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