产品详情

  • 产品名称：Anti-DLD antibody (C-Term) (STJA0010368)

  • 产品型号：STJA0010368
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DLD antibody (C-Term) (STJA0010368)
详情介绍：
Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dihydrolipoyl dehydrogenase, mitochondrial (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DLD
Gene ID: 1738
Uniprot ID: DLDH_HUMAN
Immunogen Region: C-Term
Specificity: This antibody detects endogenous levels of DLDH at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human C-ternal DLDH
Function Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
Protein Name Dihydrolipoyl Dehydrogenase - Mitochondrial
Dihydrolipoamide Dehydrogenase
Glycine Cleavage System L Protein
Database Links Reactome: R-HSA-204174
Reactome: R-HSA-389661
Reactome: R-HSA-5362517
Reactome: R-HSA-6783984
Reactome: R-HSA-70268
Reactome: R-HSA-70895
Reactome: R-HSA-71064
Reactome: R-HSA-71403
Cellular Localisation Mitochondrion Matrix
Nucleus
Cell Projection
Cilium
Flagellum
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
Mainly Localizes In The Mitochondrion
A Small Fraction Localizes To The Nucleus
Where The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation
Alternative Antibody Names Anti-Dihydrolipoyl Dehydrogenase - Mitochondrial antibody
Anti-Dihydrolipoamide Dehydrogenase antibody
Anti-Glycine Cleavage System L Protein antibody
Anti-DLD antibody
Anti-GCSL antibody
Anti-LAD antibody
Anti-PHE3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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