产品详情

  • 产品名称：Anti-DEFB4A antibody (1-64) (STJ23367)

  • 产品型号：STJ23367
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DEFB4A antibody (1-64) (STJ23367)
详情介绍：
Host: Rabbit
Applications: IHC
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DEFB4A (1-64) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:100-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DEFB4A.DEFB4B
Gene ID: 100289462/1673
Uniprot ID: DFB4A_HUMAN
Immunogen Region: 1-64
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-64 of human DEFB4A (NP_004933.1).
Immunogen Sequence: MRVLYLLFSFLFIFLMPLPG VFGGIGDPVTCLKSGAICHP VFCPRRYKQIGTCGLPGTKC CKKP
Tissue Specificity Expressed in lung epithelial cells (at protein level). Expressed in foreskin, lung and trachea. Lower expression in kidney, uterus and salivary gland tissue. Expressed in epithelial cells of the respiratory tract, with higher expression in distal parenchyma of the lung, trachea, and tonsils, and lower expression in pharynx and adenoid, and low expression in tongue and larynx.
Function Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria. Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM. Also exhibits antimicrobial activity against the yeast C.albicans. Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death. Acts as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells.
Protein Name Defensin Beta 4a
Beta-Defensin 2
Bd-2
Hbd-2
Defensin - Beta 2
Skin-Antimicrobial Peptide 1
Sap1
Database Links Reactome: R-HSA-1461957
Reactome: R-HSA-1461973
Cellular Localisation Secreted
Alternative Antibody Names Anti-Defensin Beta 4a antibody
Anti-Beta-Defensin 2 antibody
Anti-Bd-2 antibody
Anti-Hbd-2 antibody
Anti-Defensin - Beta 2 antibody
Anti-Skin-Antimicrobial Peptide 1 antibody
Anti-Sap1 antibody
Anti-DEFB4A antibody
Anti-DEFB102 antibody
Anti-DEFB2 antibody
Anti-DEFB4.DEFB4B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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