产品详情

  • 产品名称：Mouse FFAR2 (Free Fatty Acid Receptor 2) Sandwich ELISA Kit (STJE0008846)

  • 产品型号：STJE0008846
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse FFAR2 (Free Fatty Acid Receptor 2) Sandwich ELISA Kit (STJE0008846)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This FFAR2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Ffar2
Gene ID: 233079
Uniprot ID: FFAR2_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Highly expressed in hematopoietic tissues, such as spleen and bone marrow, with highest levels in a subset of immune cells, including monocytes or neutrophils. Expressed in adipose tissues with high expression in differentiating adipocytes. Expressed by intestinal endocrine cells.
Post Translational Modifications
Function G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes.
Protein Name Free Fatty Acid Receptor 2
G-Protein Coupled Receptor 43
Leukocyte-Specific Stat-Induced Gpcr
Database Links Reactome: R-MMU-416476
Reactome: -MMU-444209
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Free Fatty Acid Receptor 2 ELISA kit
G-Protein Coupled Receptor 43 ELISA kit
Leukocyte-Specific Stat-Induced Gpcr ELISA kit
Ffar2 ELISA kit
Gpr43 ELISA kit
Lssig ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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