产品详情

  • 产品名称：Anti-Cd274/PD-L1 antibody [10F.9G2] (STJA0001820)

  • 产品型号：STJA0001820
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-Cd274/PD-L1 antibody [10F.9G2] (STJA0001820)
详情介绍：
Host: Rat
Applications: FC/IHC/IF/Block
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Programmed cell death 1 ligand 1 is suitable for use in Flow Cytometry, Immunohistochemistry, Immunofluorescence and Universal research applications.
Clonality: Monoclonal
Clone ID: 10F.9G2
Conjugation: Unconjugated
Isotype: IgG2bk
Formulation: 0.2 µm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as determined by LAL gel clotting assay.
Concentration: 0.5 mg/mL
Storage Instruction: Store at 2-8°C. Do not freeze this product.
Gene Symbol: Cd274
Gene ID: 60533
Uniprot ID: PD1L1_MOUSE
Tissue Specificity Highly expressed in the heart, thymus, skeletal muscle, and lung. Weakly expressed in the kidney, spleen, thyroid, and liver. Expressed on activated dendritic cells, B-cells and macrophages. Expressed in numerous tumor cells lines of lymphoid origin.
Post Translational Modifications Ubiquitinated.STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation. Ubiquitinated by MARCHF8.leading to degradation.
Function Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Protein Name Programmed Cell Death 1 Ligand 1
Pd-L1
Pdcd1 Ligand 1
Programmed Death Ligand 1
B7 Homolog 1
B7-H1
Cd Antigen Cd274
Database Links Reactome: R-MMU-389948
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Alternative Antibody Names Anti-Programmed Cell Death 1 Ligand 1 antibody
Anti-Pd-L1 antibody
Anti-Pdcd1 Ligand 1 antibody
Anti-Programmed Death Ligand 1 antibody
Anti-B7 Homolog 1 antibody
Anti-B7-H1 antibody
Anti-Cd Antigen Cd274 antibody
Anti-Cd274 antibody
Anti-B7h1 antibody
Anti-Pdcd1l1 antibody
Anti-Pdcd1lg1 antibody
Anti-Pdl1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 
网站地图