产品详情

  • 产品名称：Anti-DCLRE1C antibody (1-300) (STJ11105709)

  • 产品型号：STJ11105709
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-DCLRE1C antibody (1-300) (STJ11105709)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Protein Artemis (1-300) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DCLRE1C
Gene ID: 64421
Uniprot ID: DCR1C_HUMAN
Immunogen Region: 1-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DCLRE1C (NP_001029027.1).
Immunogen Sequence: MSSFEGQMAEYPTISIDRFD RENLRARAYFLSHCHKDHMK GLRAPTLKRRLECSLKVYLY CSPVTKELLLTSPKYRFWKK RIISIEIETPTQISLVDEAS GEKEEIVVTLLPAGHCPGSV MFLFQGNNGTVLYTGDFRLA QGEAARMELLHSGGRVKDIQ SVYLDTTFCDPRFYQIPSRE ECLSGVLELVRSWITRSPYH VVWLNCKAAYGYEYLFTNLS EELGVQVHVNKLDMFRNMP
Tissue Specificity Ubiquitously expressed, with highest levels in the kidney, lung, pancreas and placenta (at the mRNA level). Expression is not increased in thymus or bone marrow, sites of V(D)J recombination.
Post Translational Modifications Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening. Also phosphorylated by ATM in response to ionizing radiation (IR) and by ATR in response to ultraviolet (UV) radiation.
Function Nuclease involved in DNA non-homologous end joining (NHEJ).required for double-strand break repair and V(D)J recombination. Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Protein Name Protein Artemis
Dna Cross-Link Repair 1c Protein
Protein A-Scid
Snm1 Homolog C
Hsnm1c
Snm1-Like Protein
Database Links Reactome: R-HSA-5693571
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Protein Artemis antibody
Anti-Dna Cross-Link Repair 1c Protein antibody
Anti-Protein A-Scid antibody
Anti-Snm1 Homolog C antibody
Anti-Hsnm1c antibody
Anti-Snm1-Like Protein antibody
Anti-DCLRE1C antibody
Anti-ARTEMIS antibody
Anti-ASCID antibody
Anti-SCIDA antibody
Anti-SNM1C antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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