产品详情

  • 产品名称：Anti-CYP2D6 antibody (341-497) [S2MR] (STJ11102492)

  • 产品型号：STJ11102492
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CYP2D6 antibody (341-497) [S2MR] (STJ11102492)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CYP2D6 (341-497) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S2MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP2D6
Gene ID: 1565
Uniprot ID: CP2D6_HUMAN
Immunogen Region: 341-497
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 341-497 of human CYP2D6 (P10635).
Immunogen Sequence: QVRRPEMGDQAHMPYTTAVI HEVQRFGDIVPLGVTHMTSR DIEVQGFRIPKGTTLITNLS SVLKDEAVWEKPFRFHPEHF LDAQGHFVKPEAFLPFSAGR RACLGEPLARMELFLFFTSL LQHFSFSVPTGQPRPSHHGV FAFLVSPSPYELCAVPR
Function A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid. Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Protein Name Cytochrome P450 2d6
Cypiid6
Cholesterol 25-Hydroxylase
Cytochrome P450-Db1
Debrisoquine 4-Hydroxylase
Database Links Reactome: R-HSA-211935
Reactome: R-HSA-211958
Reactome: R-HSA-211981
Reactome: R-HSA-211999
Reactome: R-HSA-9027307
Reactome: R-HSA-9749641
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Microsome Membrane
Alternative Antibody Names Anti-Cytochrome P450 2d6 antibody
Anti-Cypiid6 antibody
Anti-Cholesterol 25-Hydroxylase antibody
Anti-Cytochrome P450-Db1 antibody
Anti-Debrisoquine 4-Hydroxylase antibody
Anti-CYP2D6 antibody
Anti-CYP2DL1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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