产品详情

  • 产品名称：Anti-CSNK2A2 antibody (250-350) (STJ23245)

  • 产品型号：STJ23245
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CSNK2A2 antibody (250-350) (STJ23245)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CSNK2A2 (250-350) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CSNK2A2
Gene ID: 1459
Uniprot ID: CSK22_HUMAN
Immunogen Region: 250-350
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CSNK2A2 (NP_001887.1).
Immunogen Sequence: LGTEELYGYLKKYHIDLDPH FNDILGQHSRKRWENFIHSE NRHLVSPEALDLLDKLLRYD HQQRLTAKEAMEHPYFYPVV KEQSQPCADNAVLSSGLTAA R
Function Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
Protein Name Casein Kinase Ii Subunit Alpha'
Ck Ii Alpha'
Database Links Reactome: R-HSA-1483191
Reactome: R-HSA-201688
Reactome: R-HSA-2514853
Reactome: R-HSA-445144
Reactome: R-HSA-6804756
Reactome: R-HSA-6814122
Reactome: R-HSA-8934903
Reactome: R-HSA-8939243
Reactome: R-HSA-8948751
Reactome: R-HSA-9755511
Cellular Localisation Nucleus
Cytoplasm
Interaction With Sirt6 Prevents Translocations Into The Nucleus
Alternative Antibody Names Anti-Casein Kinase Ii Subunit Alpha' antibody
Anti-Ck Ii Alpha' antibody
Anti-CSNK2A2 antibody
Anti-CK2A2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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