产品详情

  • 产品名称：Anti-Csk antibody [CSK-04] (STJ16100298)

  • 产品型号：STJ16100298-01
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-Csk antibody [CSK-04] (STJ16100298)
详情介绍：
Host: Mouse
Applications: WB/IP/ICC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Csk is suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry research applications.
Clonality: Monoclonal
Clone ID: CSK-04
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CSK
Gene ID: 1445
Uniprot ID: CSK_HUMAN
Immunogen: Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.
Tissue Specificity Expressed in lung and macrophages.
Post Translational Modifications Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Protein Name Tyrosine-Protein Kinase Csk
C-Src Kinase
Protein-Tyrosine Kinase Cyl
Database Links Reactome: R-HSA-180292
Reactome: R-HSA-202427
Reactome: R-HSA-354192
Reactome: R-HSA-389948
Reactome: R-HSA-5674135
Reactome: R-HSA-6802946
Reactome: R-HSA-6802948
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-9013407
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Reactome: R-HSA-9706369
Cellular Localisation Cytoplasm
Cell Membrane
Mainly Cytoplasmic
Also Present In Lipid Rafts
Alternative Antibody Names Anti-Tyrosine-Protein Kinase Csk antibody
Anti-C-Src Kinase antibody
Anti-Protein-Tyrosine Kinase Cyl antibody
Anti-CSK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 
网站地图