产品详情

  • 产品名称：Anti-CPSF7 antibody (50-240) (STJ115819)

  • 产品型号：STJ115819
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CPSF7 antibody (50-240) (STJ115819)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FLJ12529 (50-240) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CPSF7
Gene ID: 79869
Uniprot ID: CPSF7_HUMAN
Immunogen Region: 50-240
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human FLJ12529 (NP_079087.3).
Immunogen Sequence: LIDIYADEEFNQDPEFNNTD QIDLYDDVLTATSQPSDDRS SSTEPPPPVRQEPSPKPNNK TPAILYTYSGLRNRRAAVYV GSFSWWTTDQQLIQVIRSIG VYDVVELKFAENRANGQSKG YAEVVVASENSVHKLLELLP GKVLNGEKVDVRPATRQNLS QFEAQARKRECVRVPRGGIP PRAHSRDSSDS
Post Translational Modifications Phosphorylated. Asymmetrically dimethylated on arginine residues by PRMT1.
Function Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates.
Protein Name Cleavage And Polyadenylation Specificity Factor Subunit 7
Cleavage And Polyadenylation Specificity Factor 59 Kda Subunit
Cpsf 59 Kda Subunit
Cleavage Factor Im Complex 59 Kda Subunit
Cfim59
Pre-Mrna Cleavage Factor Im 59 Kda Subunit
Database Links Reactome: R-HSA-72187
Reactome: R-HSA-72203
Reactome: R-HSA-73856
Reactome: R-HSA-77595
Reactome: R-HSA-9013422
Cellular Localisation Nucleus
Cytoplasm
Shuttles Between The Nucleus And The Cytoplasm In A Transcription- And Xpo1/Crm1-Independent Manner
Most Probably In Complex With The Cleavage Factor Im Complex (Cfim)
Alternative Antibody Names Anti-Cleavage And Polyadenylation Specificity Factor Subunit 7 antibody
Anti-Cleavage And Polyadenylation Specificity Factor 59 Kda Subunit antibody
Anti-Cpsf 59 Kda Subunit antibody
Anti-Cleavage Factor Im Complex 59 Kda Subunit antibody
Anti-Cfim59 antibody
Anti-Pre-Mrna Cleavage Factor Im 59 Kda Subunit antibody
Anti-CPSF7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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