产品详情

  • 产品名称：Anti-Cleaved-F11-Ile388, Light Chain antibody (387-388) (STJA0005838)

  • 产品型号：STJA0005838
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-Cleaved-F11-Ile388, Light Chain antibody (387-388) (STJA0005838)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Coagulation factor XI-Ile388, Light Chain (387-388) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: F11
Gene ID: 2160
Uniprot ID: FA11_HUMAN
Immunogen Region: 387-388
Specificity: This antibody detects endogenous levels of Human, Mouse FA11 (light chain, Cleaved-Ile388, protein was cleaved amino acid sequence between 387-388 )
Immunogen: Synthesized peptide derived from human FA11 (light chain, Cleaved-Ile388)
Tissue Specificity Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
Post Translational Modifications N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
Function Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Protein Name Coagulation Factor Xi
Fxi
Plasma Thromboplastin Antecedent
Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain
Database Links Reactome: R-HSA-140837
Reactome: R-HSA-9673221
Cellular Localisation Secreted
Alternative Antibody Names Anti-Coagulation Factor Xi antibody
Anti-Fxi antibody
Anti-Plasma Thromboplastin Antecedent antibody
Anti-Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain antibody
Anti-F11 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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