产品详情

  • 产品名称：Human SLC16A1 (Solute Carrier Family 16, Member 1) Sandwich ELISA Kit (STJE0012187)

  • 产品型号：STJE0012187
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human SLC16A1 (Solute Carrier Family 16, Member 1) Sandwich ELISA Kit (STJE0012187)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.116ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This SLC16A1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SLC16A1
Gene ID: 6566
Uniprot ID: MOT1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed. Detected in heart and in blood lymphocytes and monocytes (at protein level).
Post Translational Modifications
Function Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart. Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition.
Protein Name Monocarboxylate Transporter 1
Mct 1
Solute Carrier Family 16 Member 1
Database Links Reactome: R-HSA-210991
Reactome: R-HSA-433692
Reactome: R-HSA-5619070
Reactome: R-HSA-70268
Reactome: R-HSA-9749641
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Apical Cell Membrane
Expression At The Cell Surface Requires The Ancillary Proteins Bsg And Emb
Binds Preferentially To Bsg
Alternative ELISA Names Monocarboxylate Transporter 1 ELISA kit
Mct 1 ELISA kit
Solute Carrier Family 16 Member 1 ELISA kit
SLC16A1 ELISA kit
MCT1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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