产品详情

  • 产品名称：Anti-CHMP4B antibody (50-100) (STJA0006482)

  • 产品型号：STJA0006482
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CHMP4B antibody (50-100) (STJA0006482)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Charged multivesicular body protein 4b (50-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHMP4B
Gene ID: 128866
Uniprot ID: CHM4B_HUMAN
Immunogen Region: 50-100
Specificity: This antibody detects endogenous levels of human CHM4B
Immunogen: Synthesized peptide derived from human CHM4B AA range: 50-100
Post Translational Modifications ISGylated. Isgylation weakens its interaction with VPS4A.
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan. (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.
Protein Name Charged Multivesicular Body Protein 4b
Chromatin-Modifying Protein 4b
Chmp4b
Snf7 Homolog Associated With Alix 1
Snf7-2
Hsnf7-2
Vacuolar Protein Sorting-Associated Protein 32-2
Vps32-2
Hvps32-2
Database Links Reactome: R-HSA-162588
Reactome: R-HSA-1632852
Reactome: R-HSA-5620971
Reactome: R-HSA-917729
Reactome: R-HSA-9610379
Reactome: R-HSA-9615710
Reactome: R-HSA-9668328
Reactome: R-HSA-9679504
Reactome: R-HSA-9694676
Cellular Localisation Cytoplasm
Cytosol
Late Endosome Membrane
Peripheral Membrane Protein
Midbody
Nucleus Envelope
Recruited To The Nuclear Envelope By Chmp7 During Late Anaphase
Localizes Transiently To The Midbody Arms Immediately Before Abscission
Alternative Antibody Names Anti-Charged Multivesicular Body Protein 4b antibody
Anti-Chromatin-Modifying Protein 4b antibody
Anti-Chmp4b antibody
Anti-Snf7 Homolog Associated With Alix 1 antibody
Anti-Snf7-2 antibody
Anti-Hsnf7-2 antibody
Anti-Vacuolar Protein Sorting-Associated Protein 32-2 antibody
Anti-Vps32-2 antibody
Anti-Hvps32-2 antibody
Anti-CHMP4B antibody
Anti-C20orf178 antibody
Anti-SHAX1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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