产品详情

  • 产品名称：Human PRAME (Preferentially Expressed Antigen In Melanoma) Sandwich ELISA Kit Ready-To-Use (STJE0018022)

  • 产品型号：STJE0018022
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human PRAME (Preferentially Expressed Antigen In Melanoma) Sandwich ELISA Kit Ready-To-Use (STJE0018022)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.105ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This PRAME Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: PRAME
Gene ID: 23532
Uniprot ID: PRAME_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Expressed in testis. Detected in samples of kidney, brain and skin.
Post Translational Modifications
Function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
Protein Name Melanoma Antigen Preferentially Expressed In Tumors
Opa-Interacting Protein 4
Oip-4
Preferentially Expressed Antigen Of Melanoma
Database Links
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Golgi Apparatus
Cell Membrane
Associates With Chromatin
Specifically Enriched At Transcriptionally Active Promoters That Are Also Bound By Nuclear Transcription Factor Y (Composed Of Nfya
Nfyb And Nfyc) And At Enhancers
Recruited To The Golgi Apparatus In Response To Interferon Gamma (Ifng) Treatment
Alternative ELISA Names Melanoma Antigen Preferentially Expressed In Tumors ELISA kit
Opa-Interacting Protein 4 ELISA kit
Oip-4 ELISA kit
Preferentially Expressed Antigen Of Melanoma ELISA kit
PRAME ELISA kit
MAPE ELISA kit
OIP4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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