产品详情

  • 产品名称：Anti-CXCR4 antibody (15-65) {FITC} (STJ500662)

  • 产品型号：STJ500662-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CXCR4 antibody (15-65) {FITC} (STJ500662)
详情介绍：
Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CXCR4 (15-65) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.68-0.75 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:250
IHC: 1:250
ICC: 1:250
IF: 1:250
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CXCR4
Gene ID: 7852
Uniprot ID: CXCR4_HUMAN
Immunogen Region: 15-65
Immunogen: Synthetic peptide taken within amino acid region 15-65 on CXCR4 protein.
Tissue Specificity Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.
Post Translational Modifications Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation. Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S. Sulfation on Tyr-21 is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization. Tyr-7 and Tyr-12 are sulfated in a sequential manner after Tyr-21 is almost fully sulfated, with the binding affinity for CXCL12/SDF-1alpha increasing with the number of sulfotyrosines present. Sulfotyrosines Tyr-7 and Tyr-12 occupy clefts on opposing CXCL12 subunits, thus bridging the CXCL12 dimer interface and promoting CXCL12 dimerization. O- and N-glycosylated. Asn-11 is the principal site of N-glycosylation. There appears to be very little or no glycosylation on Asn-176. N-glycosylation masks coreceptor function in both X4 and R5 laboratory-adapted and primary HIV-1 strains through inhibiting interaction with their Env glycoproteins. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.
Function Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin.leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
Protein Name C-X-C Chemokine Receptor Type 4
Cxc-R4
Cxcr-4
Fb22
Fusin
Hm89
Lcr1
Leukocyte-Derived Seven Transmembrane Domain Receptor
Lestr
Lipopolysaccharide-Associated Protein 3
Lap-3
Lps-Associated Protein 3
Npyrl
Stromal Cell-Derived Factor 1 Receptor
Sdf-1 Receptor
Cd Antigen Cd184
Database Links Reactome: R-HSA-173107
Reactome: R-HSA-376176
Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-9823730
Reactome: R-HSA-9827857
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Junction
Early Endosome
Late Endosome
Lysosome
In Unstimulated Cells
Diffuse Pattern On Plasma Membrane
On Agonist Stimulation
Colocalizes With Itch At The Plasma Membrane Where It Becomes Ubiquitinated
In The Presence Of Antigen
Distributes To The Immunological Synapse Forming At The T-Cell-Apc Contact Area
Where It Localizes At The Peripheral And Distal Supramolecular Activation Cluster (Smac)
Alternative Antibody Names Anti-C-X-C Chemokine Receptor Type 4 antibody
Anti-Cxc-R4 antibody
Anti-Cxcr-4 antibody
Anti-Fb22 antibody
Anti-Fusin antibody
Anti-Hm89 antibody
Anti-Lcr1 antibody
Anti-Leukocyte-Derived Seven Transmembrane Domain Receptor antibody
Anti-Lestr antibody
Anti-Lipopolysaccharide-Associated Protein 3 antibody
Anti-Lap-3 antibody
Anti-Lps-Associated Protein 3 antibody
Anti-Npyrl antibody
Anti-Stromal Cell-Derived Factor 1 Receptor antibody
Anti-Sdf-1 Receptor antibody
Anti-Cd Antigen Cd184 antibody
Anti-CXCR4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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