产品详情

  • 产品名称：Anti-CXCL8 antibody [1501] (STJ400116)

  • 产品型号：STJ400116
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CXCL8 antibody [1501] (STJ400116)
详情介绍：
Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CXCL8 is suitable for use in ELISA research applications.
Clonality: Monoclonal
Clone ID: 1501
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Purification: Purity accurate to greater than or equal to 95%
Concentration: 5.0 mg/ml (+/-10 %)
Storage Instruction: 18 months from manufacturing at 2°C. Temperature analysis:-70 °C, 21 days N/D-20 °C, 21 days OK +4 °C, 21 days OK +30 °C, 21 OK +35 °C, 21 days OK +45 °C, 7 days OK. Shelf life stability testing at 2–8 °C in the product buffer.
Association Rate Constant: 8.9 x 105 1/Ms
Determination Method: SPR analysis (ProteOn XPR36)
Immunoreactivity: 80–120 % compared to the reference sample in an FIA test
Gene Symbol: CXCL8
Gene ID: 3576
Uniprot ID: IL8_HUMAN
Immunogen: human interleukin-8
Post Translational Modifications Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. (Microbial infection) Cleaved by group A Streptococcus protease SpyCEP.leading to impaired neutrophil endothelial transmigration and thus increased virulence.
Function Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
Protein Name Interleukin-8
Il-8
C-X-C Motif Chemokine 8
Chemokine
C-X-C Motif Ligand 8
Emoctakin
Granulocyte Chemotactic Protein 1
Gcp-1
Monocyte-Derived Neutrophil Chemotactic Factor
Mdncf
Monocyte-Derived Neutrophil-Activating Peptide
Monap
Neutrophil-Activating Protein 1
Nap-1
Protein 3-10c
T-Cell Chemotactic Factor Cleaved Into - Mdncf-A
Gcp/Il-8 Protein Iv
Il8/Nap1 Form I - Interleukin-8
(Ala-Il-877
Gcp/Il-8 Protein Ii
Il-8(1-77
Il8/Nap1 Form Ii
Mdncf-B - Il-8(5-77 - Il-8(6-77
(Ser-Il-872
Gcp/Il-8 Protein I
Il8/Nap1 Form Iii
Lymphocyte-Derived Neutrophil-Activating Factor
Lynap
Mdncf-C
Neutrophil-Activating Factor
Naf - Il-8(7-77
Gcp/Il-8 Protein V
Il8/Nap1 Form Iv - Il-8(8-77
Gcp/Il-8 Protein Vi
Il8/Nap1 Form V - Il-8(9-77
Gcp/Il-8 Protein Iii
Il8/Nap1 Form Vi
Database Links Reactome: R-HSA-2559582
Reactome: R-HSA-375276
Reactome: R-HSA-380108
Reactome: R-HSA-380994
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interleukin-8 antibody
Anti-Il-8 antibody
Anti-C-X-C Motif Chemokine 8 antibody
Anti-Chemokine antibody
Anti-C-X-C Motif Ligand 8 antibody
Anti-Emoctakin antibody
Anti-Granulocyte Chemotactic Protein 1 antibody
Anti-Gcp-1 antibody
Anti-Monocyte-Derived Neutrophil Chemotactic Factor antibody
Anti-Mdncf antibody
Anti-Monocyte-Derived Neutrophil-Activating Peptide antibody
Anti-Monap antibody
Anti-Neutrophil-Activating Protein 1 antibody
Anti-Nap-1 antibody
Anti-Protein 3-10c antibody
Anti-T-Cell Chemotactic Factor Cleaved Into - Mdncf-A antibody
Anti-Gcp/Il-8 Protein Iv antibody
Anti-Il8/Nap1 Form I - Interleukin-8 antibody
Anti-(Ala-Il-877 antibody
Anti-Gcp/Il-8 Protein Ii antibody
Anti-Il-8(1-77 antibody
Anti-Il8/Nap1 Form Ii antibody
Anti-Mdncf-B - Il-8(5-77 - Il-8(6-77 antibody
Anti-(Ser-Il-872 antibody
Anti-Gcp/Il-8 Protein I antibody
Anti-Il8/Nap1 Form Iii antibody
Anti-Lymphocyte-Derived Neutrophil-Activating Factor antibody
Anti-Lynap antibody
Anti-Mdncf-C antibody
Anti-Neutrophil-Activating Factor antibody
Anti-Naf - Il-8(7-77 antibody
Anti-Gcp/Il-8 Protein V antibody
Anti-Il8/Nap1 Form Iv - Il-8(8-77 antibody
Anti-Gcp/Il-8 Protein Vi antibody
Anti-Il8/Nap1 Form V - Il-8(9-77 antibody
Anti-Gcp/Il-8 Protein Iii antibody
Anti-Il8/Nap1 Form Vi antibody
Anti-CXCL8 antibody
Anti-IL8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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