产品详情

  • 产品名称：Anti-CXADR antibody (20-237) (STJ23296)

  • 产品型号：STJ23296
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CXADR antibody (20-237) (STJ23296)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CXADR (20-237) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CXADR
Gene ID: 1525
Uniprot ID: CXAR_HUMAN
Immunogen Region: 20-237
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-237 of human CAR/CXADR (NP_001329.1).
Immunogen Sequence: LSITTPEEMIEKAKGETAYL PCKFTLSPEDQGPLDIEWLI SPADNQKVDQVIILYSGDKI YDDYYPDLKGRVHFTSNDLK SGDASINVTNLQLSDIGTYQ CKVKKAPGVANKKIHLVVLV KPSGARCYVDGSEEIGSDFK IKCEPKEGSLPLQYEWQKLS DSQKMPTSWLAEMTSSVISV KNASSEYSGTYSCTVRNRVG SDQCLLRLNVVPPSNKAG
Tissue Specificity Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
Post Translational Modifications N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260.required for proper localization to the plasma membrane.
Function Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
Protein Name Coxsackievirus And Adenovirus Receptor
Car
Hcar
Cvb3-Binding Protein
Coxsackievirus B-Adenovirus Receptor
Hcvadr
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-202733
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Basolateral Cell Membrane
Cell Junction
Tight Junction
Adherens Junction
In Epithelial Cells Localizes To The Apical Junction Complex Composed Of Tight And Adherens Junctions
In Airway Epithelial Cells Localized To Basolateral Membrane But Not To Apical Surface
Isoform 3: Secreted
Isoform 4: Secreted
Isoform 5: Secreted
Alternative Antibody Names Anti-Coxsackievirus And Adenovirus Receptor antibody
Anti-Car antibody
Anti-Hcar antibody
Anti-Cvb3-Binding Protein antibody
Anti-Coxsackievirus B-Adenovirus Receptor antibody
Anti-Hcvadr antibody
Anti-CXADR antibody
Anti-CAR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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