产品详情

  • 产品名称：Mouse CaN (Calcineurin) Sandwich ELISA Kit Ready-To-Use (STJE0014040)

  • 产品型号：STJE0014040
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse CaN (Calcineurin) Sandwich ELISA Kit Ready-To-Use (STJE0014040)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This CaN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Ppp3ca
Gene ID: 19055
Uniprot ID: PP2BA_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in the kidney (at protein level). Expressed in the salivary gland (at protein level). Expressed in osteoblasts and bone marrow (at protein level). Expressed in the brain and the bicep, tricep, soleus and gastrocnemius muscles (at protein level). Abundantly expressed in the dentate gyrus and the CA1 and CA3 regions of the hippocampus (at protein level). Expressed in T-lymphocytes (at protein level). Expressed in embryonic stem cells.
Post Translational Modifications
Function Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocations to the mitochondrion. Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. Dephosphorylates heat shock protein HSPB1. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins. Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function. Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration. Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands. Required for calcineurin activity and homosynaptic depotentiation in the hippocampus. Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation. Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation. Positively regulates osteoclast differentiation, potentially via NFATC1 signaling. May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocations of the transcription factors RELA and RELB. Required for antigen-specific T-cell proliferation response. Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4. Negatively regulates SLC9A1 activity.
Protein Name Protein Phosphatase 3 Catalytic Subunit Alpha
Cam-Prp Catalytic Subunit
Calcineurin A Alpha
Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform
Cna Alpha
Serine/Threonine-Protein Phosphatase 2b Catalytic Subunit Alpha Isoform
Database Links Reactome: R-MMU-2025928
Reactome: -MMU-2871809
Reactome: -MMU-4086398
Reactome: -MMU-5607763
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Sarcolemma
Myofibril
Sarcomere
Z Line
Cell Projection
Dendritic Spine
Colocalizes With Actn1 And Myoz2 At The Z Line In Heart And Skeletal Muscle
Recruited To The Cell Membrane By Scaffold Protein Akap5 Following L-Type Ca(2+)-Channel Activation
Alternative ELISA Names Protein Phosphatase 3 Catalytic Subunit Alpha ELISA kit
Cam-Prp Catalytic Subunit ELISA kit
Calcineurin A Alpha ELISA kit
Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform ELISA kit
Cna Alpha ELISA kit
Serine/Threonine-Protein Phosphatase 2b Catalytic Subunit Alpha Isoform ELISA kit
Ppp3ca ELISA kit
Calna ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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