产品详情

  • 产品名称：Mouse CACNa1C (Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit) Sandwich ELISA Kit (STJE0007634)

  • 产品型号：STJE0007634
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse CACNa1C (Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit) Sandwich ELISA Kit (STJE0007634)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.115ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This CACNa1C Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Cacna1c
Gene ID: 12288
Uniprot ID: CAC1C_MOUSE
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Detected in embryonic heart. Detected in retina in rod bipolar cells. Detected in tibialis artery (at protein level). Detected in smooth muscle cells from tibialis artery and in mesenteric artery. High expression in heart, followed by brain and spinal cord.
Post Translational Modifications Phosphorylation by PKA at Ser-1897 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA.
Function Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle
Melc-Cc
Mouse Brain Class C
Mbc
Voltage-Gated Calcium Channel Subunit Alpha Cav1.2
Database Links Reactome: R-MMU-422356
Reactome: -MMU-5576892
Reactome: -MMU-5576893
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Sarcolemma
Perikaryon
Postsynaptic Density Membrane
Cell Projection
Dendrite
T-Tubule
Colocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional Membrane
Where The Sarcolemma And The Sarcoplasmic Reticulum Are In Close Contact
The Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell Membrane
Localized In T-Tubules
As Shown In Serca2-Knockout Cardiomyocytes
Alternative ELISA Names Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c ELISA kit
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle ELISA kit
Melc-Cc ELISA kit
Mouse Brain Class C ELISA kit
Mbc ELISA kit
Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 ELISA kit
Cacna1c ELISA kit
Cach2 ELISA kit
Cacn2 ELISA kit
Cacnl1a1 ELISA kit
Cchl1a1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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