产品详情

  • 产品名称：Anti-CTR1/SLC31A1 antibody (1-100) [S0MR] (STJ11102710)

  • 产品型号：STJ11102710
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CTR1/SLC31A1 antibody (1-100) [S0MR] (STJ11102710)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CTR1/SLC31A1 (1-100) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S0MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC31A1
Gene ID: 1317
Uniprot ID: COPT1_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CTR1/SLC31A1 (NP_001850.1).
Immunogen Sequence: MDHSHHMGMSYMDSNSTMQP SHHHPTTSASHSHGGGDSSM MMMPMTFYFGFKNVELLFSG LVINTAGEMAGAFVAVFLLA MFYEGLKIARESLLRKSQVS
Post Translational Modifications O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain. Proteolytic cleavage, leading to a truncated form, is facilitated by SLC31A2 and initiated preferentially by CTSL and to a minor extend by CTSB in endolysosomal compartments. In vitro, is cleaved by CTSL/cathepsin L between residues 8 and 9 from the amino terminus. A post-CTSL/cathepsin L processing occurs to yield to the fully truncated form. Sulfenylated at Cys-189 after stimulation with VEGFA, which induces SLC31A1-KDR disulfide bond formation and their co-internalization to early endosomes, driving to a sustained VEGFR2 signaling.
Function High affinity copper uptake protein 1: Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane and delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels. May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption. The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity. Also mediates the uptake of silver(1+). May function in the influx of the platinum-containing chemotherapeutic agents. The platinum-containing chemotherapeutic agents uptake is saturable. In vitro, mediates the transport of cadmium(2+) into cells. Also participates in the first step of copper(2+) acquisition by cells through a direct transfer of copper(2+) from copper(2+) carriers in blood, such as ALB to the N-terminal domain of SLC31A1, leading to copper(2+) reduction and probably followed by copper(1+) stabilization. In addition, functions as a redox sensor to promote angiogenesis in endothelial cells, in a copper(1+) transport independent manner, by transmitting the VEGF-induced ROS signal through a sulfenylation at Cys-189 leadin g to a subsequent disulfide bond formation between SLC31A1 and KDR. The SLC31A1-KDR complex is then co-internalized to early endosomes, driving a sustained VEGFR2 signaling. Truncated CTR1 form: Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells.
Protein Name High Affinity Copper Uptake Protein 1
Copper Transporter 1
Hctr1
Solute Carrier Family 31 Member 1 Cleaved Into - Truncated Ctr1 Form
Database Links Reactome: R-HSA-425410
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Apical Cell Membrane
Late Endosome Membrane
Basolateral Cell Membrane
The Localization Is Controlled By The Intra And Extra-Cellular Copper Concentration
Under Conditions Of Elevated Extracellular Copper Concentrations
It Is Rapidly Internalized By Endocytosis From The Plasma Membrane By A Clathrin- And Dynamin-Mediated Process And Degradated In Order To Prevent Intracellular Copper Accumulation And To Reduce The Transport Of The Copper Across The Membrane
The Internalized Slc31a1 Is Then Localized In Early Endosomes
And
Upon A Low Extracellular Copper Concentrations
It Is Transported Back To The Plasma Membrane In A Rab11a-Dependent Recycling Pathway
Localizes To The Apical Membrane In Intestinal Epithelial Cells
Mainly Localized On The Basolateral Side Of Renal Tubular Cells
Localizes To The Neuronal Cell Body Plasma Membranes
Alternative Antibody Names Anti-High Affinity Copper Uptake Protein 1 antibody
Anti-Copper Transporter 1 antibody
Anti-Hctr1 antibody
Anti-Solute Carrier Family 31 Member 1 Cleaved Into - Truncated Ctr1 Form antibody
Anti-SLC31A1 antibody
Anti-COPT1 antibody
Anti-CTR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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