产品详情

  • 产品名称：Anti-CSNK1A1 antibody (238-337) [S5MR] (STJ11102475)

  • 产品型号：STJ11102475
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CSNK1A1 antibody (238-337) [S5MR] (STJ11102475)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CSNK1A1 (238-337) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S5MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CSNK1A1
Gene ID: 1452
Uniprot ID: KC1A_HUMAN
Immunogen Region: 238-337
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 238-337 of human Casein Kinase 1 alpha (CSNK1A1) (P48729).
Immunogen Sequence: EKKMSTPVEVLCKGFPAEFA MYLNYCRGLRFEEAPDYMYL RQLFRILFRTLNHQYDYTFD WTMLKQKAAQQAASSSGQGQ QAQTPTGKQTDKTKSNMKGF
Post Translational Modifications Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation.
Function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor. Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3.
Protein Name Casein Kinase I Isoform Alpha
Cki-Alpha
Ck1
Database Links Reactome: R-HSA-195253
Reactome: R-HSA-196299
Reactome: R-HSA-4641262
Reactome: R-HSA-5339716
Reactome: R-HSA-5358747
Reactome: R-HSA-5358749
Reactome: R-HSA-5358751
Reactome: R-HSA-5358752
Reactome: R-HSA-5467337
Reactome: R-HSA-5467340
Reactome: R-HSA-5467348
Reactome: R-HSA-5610783
Reactome: R-HSA-5610785
Reactome: R-HSA-5635838
Reactome: R-HSA-9694631
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Chromosome
Centromere
Kinetochore
Nucleus Speckle
Cilium Basal Body
Spindle
Localizes To The Centrosome In Interphase Cells
And To Kinetochore Fibers During Mitosis
Also Recruited To The Keratin Cytoskeleton
Alternative Antibody Names Anti-Casein Kinase I Isoform Alpha antibody
Anti-Cki-Alpha antibody
Anti-Ck1 antibody
Anti-CSNK1A1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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