产品详情

  • 产品名称：Anti-CRHR1 antibody (24-120) (STJ110707)

  • 产品型号：STJ110707
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CRHR1 antibody (24-120) (STJ110707)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CRHR1 (24-120) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRHR1
Gene ID: 104909134/1394
Uniprot ID: CRFR1_HUMAN
Immunogen Region: 24-120
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-120 of human CRHR1 (NP_001138618.1).
Immunogen Sequence: SLQDQHCESLSLASNISGLQ CNASVDLIGTCWPRSPAGQL VVRPCPAFFYGVRYNTTNNG YRECLANGSWAARVNYSECQ EILNEEKKSKVHYHVAV
Tissue Specificity Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
Post Translational Modifications C-terminal Ser or Thr residues may be phosphorylated. Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.
Function G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Protein Name Corticotropin-Releasing Factor Receptor 1
Crf-R-1
Crf-R1
Crfr-1
Corticotropin-Releasing Hormone Receptor 1
Crh-R-1
Crh-R1
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-418555
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endosome
Agonist-Binding Promotes Endocytosis
Alternative Antibody Names Anti-Corticotropin-Releasing Factor Receptor 1 antibody
Anti-Crf-R-1 antibody
Anti-Crf-R1 antibody
Anti-Crfr-1 antibody
Anti-Corticotropin-Releasing Hormone Receptor 1 antibody
Anti-Crh-R-1 antibody
Anti-Crh-R1 antibody
Anti-CRHR1 antibody
Anti-CRFR antibody
Anti-CRFR1 antibody
Anti-CRHR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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