产品详情

  • 产品名称：Human XPD (Xeroderma Pigmentosum, Complementation Group D) Sandwich ELISA Kit (STJE0013125)

  • 产品型号：STJE0013125
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human XPD (Xeroderma Pigmentosum, Complementation Group D) Sandwich ELISA Kit (STJE0013125)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.056ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This XPD Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Dilution Range: °C
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ERCC2
Gene ID: 2068
Uniprot ID: ERCC2_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications ISGylated.
Function ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
Protein Name General Transcription And Dna Repair Factor Iih Helicase Subunit Xpd
Tfiih Subunit Xpd
Basic Transcription Factor 2 80 Kda Subunit
Btf2 P80
Cxpd
Dna Excision Repair Protein Ercc-2
Dna Repair Protein Complementing Xp-D Cells
Tfiih Basal Transcription Factor Complex 80 Kda Subunit
Tfiih 80 Kda Subunit
Tfiih P80
Xeroderma Pigmentosum Group D-Complementing Protein
Database Links Reactome: R-HSA-112382
Reactome: R-HSA-113418
Reactome: R-HSA-167152
Reactome: R-HSA-167158
Reactome: R-HSA-167160
Reactome: R-HSA-167161
Reactome: R-HSA-167162
Reactome: R-HSA-167172
Reactome: R-HSA-167200
Reactome: R-HSA-167246
Reactome: R-HSA-2564830
Reactome: R-HSA-427413
Reactome: R-HSA-5696395
Reactome: R-HSA-5696400
Reactome: R-HSA-674695
Reactome: R-HSA-6781823
Reactome: R-HSA-6781827
Reactome: R-HSA-6782135
Reactome: R-HSA-6782210
Reactome: R-HSA-6796648
Reactome: R-HSA-72086
Reactome: R-HSA-73762
Reactome: R-HSA-73772
Reactome: R-HSA-73776
Reactome: R-HSA-73779
Reactome: R-HSA-73863
Reactome: R-HSA-75953
Reactome: R-HSA-75955
Reactome: R-HSA-76042
Reactome: R-HSA-77075
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Spindle
Alternative ELISA Names General Transcription And Dna Repair Factor Iih Helicase Subunit Xpd ELISA kit
Tfiih Subunit Xpd ELISA kit
Basic Transcription Factor 2 80 Kda Subunit ELISA kit
Btf2 P80 ELISA kit
Cxpd ELISA kit
Dna Excision Repair Protein Ercc-2 ELISA kit
Dna Repair Protein Complementing Xp-D Cells ELISA kit
Tfiih Basal Transcription Factor Complex 80 Kda Subunit ELISA kit
Tfiih 80 Kda Subunit ELISA kit
Tfiih P80 ELISA kit
Xeroderma Pigmentosum Group D-Complementing Protein ELISA kit
ERCC2 ELISA kit
XPD ELISA kit
XPDC ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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