产品详情

  • 产品名称：Human UBQLN2 (Ubiquilin 2) Sandwich ELISA Kit Ready-To-Use (STJE0019287)

  • 产品型号：STJE0019287
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human UBQLN2 (Ubiquilin 2) Sandwich ELISA Kit Ready-To-Use (STJE0019287)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.64ng/mL
Detection Limit: 1.56-100ng/mL
Short Description: This UBQLN2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: UBQLN2
Gene ID: 29978
Uniprot ID: UBQL2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Degraded during macroautophagy.
Function Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation.required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs).
Protein Name Ubiquilin-2
Chap1
Dsk2 Homolog
Protein Linking Iap With Cytoskeleton 2
Plic-2
Hplic-2
Ubiquitin-Like Product Chap1/Dsk2
Database Links Reactome: R-HSA-8856825
Cellular Localisation Cytoplasm
Nucleus
Membrane
Cytoplasmic Vesicle
Autophagosome
Colocalizes With A Subset Of Proteasomes
Namely Those That Are Cytoskeleton Associated Or Free In The Cytosol
Associated With Fibers In Mitotic Cells
Alternative ELISA Names Ubiquilin-2 ELISA kit
Chap1 ELISA kit
Dsk2 Homolog ELISA kit
Protein Linking Iap With Cytoskeleton 2 ELISA kit
Plic-2 ELISA kit
Hplic-2 ELISA kit
Ubiquitin-Like Product Chap1/Dsk2 ELISA kit
UBQLN2 ELISA kit
N4BP4 ELISA kit
PLIC2 ELISA kit
HRIHFB2157 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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