产品详情

  • 产品名称：Anti-CCDC98 antibody (350-400) (STJ500022)

  • 产品型号：STJ500022-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCDC98 antibody (350-400) (STJ500022)
详情介绍：
Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CCDC98 (350-400) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.52-0.63 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ABRAXAS1
Gene ID: 289468
Uniprot ID: ABRX1_RAT
Immunogen Region: 350-400
Immunogen: Synthetic peptide taken within amino acid region 350-400 on rat BRCA1-A complex subunit Abraxas protein.
Post Translational Modifications Phosphorylation of Ser-402 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1.
Function Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Protein Name Brca1-A Complex Subunit Abraxas 1
Coiled-Coil Domain-Containing Protein 98
Protein Fam175a
Database Links Reactome: R-RNO-5689901
Reactome: -RNO-5693565
Reactome: -RNO-5693571
Reactome: -RNO-5693607
Reactome: -RNO-69473
Cellular Localisation Nucleus
Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
Alternative Antibody Names Anti-Brca1-A Complex Subunit Abraxas 1 antibody
Anti-Coiled-Coil Domain-Containing Protein 98 antibody
Anti-Protein Fam175a antibody
Anti-ABRAXAS1 antibody
Anti-Abra1 antibody
Anti-Ccdc98 antibody
Anti-Fam175a antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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